3D-QSAR Studies of JNK1 Inhibitors Utilizing Various Alignment Methods
نویسندگان
چکیده
منابع مشابه
An Alignment-Independent 3D-QSAR Studies of FGFR2 Tyrosine Kinase Inhibitors
2017 The Authors. This is an Open Access article distributed under the terms of the Creative Commons Attribution (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, as long as the original authors and source are cited. No permission is required from the authors or the publishers. Adv Pharm Bull, 2017, 7(x), x-x doi: 10.15171/apb.2016.000 http://apb.tbzmed.ac.i...
متن کاملStructure Based 3D-QSAR Studies on Cholinesterase Inhibitors
Alzheimer’s disease (AD) is a slowly progressive neurodegenerative disorder of the elderly. It is characterized by widespread loss of central cholinergic neuronal function (Butters et al., 1995). The only symptomatic treatment proven to be effective to date is the use of cholinesterase inhibitors (ChEI) to augment surviving cholinergic activity (Giacobini, 2003, Terry & Buccafusco, 2003). Two t...
متن کامل3D-QSAR studies on fluroquinolones derivatives as inhibitors for tuberculosis
A quantitative structure activity relationship (QSAR) study was performed on the fluroquinolones known to have anti-tuberculosis activity. The 3D-QSAR models were generated using stepwise variable selection of the four methods - multiple regression (MR), partial least square regression (PLSR), principal component regression (PCR) and artificial neural networks (kNN-MFA). The statistical result ...
متن کامل3D QSAR Studies of 1,3,4-oxadiazole derivatives as antimycobacterial agents
Recently several 1,3,4-oxadiazole derivatives were identified as potentially active antimycobacterial agents. Various 5-aryl-2-thio-1,3,4-oxadiazoles have been reported having good antimycobacterial activity against Mycobacterium tuberculosis H37Rv (ATCC 27294). In this paper we report 3D QSAR studies for the 41 molecules of 1,3,4-oxadiazoles by using k-Nearest Neighbor Molecular Field Analysis...
متن کامل3D QSAR Studies of 1,3,4-oxadiazole derivatives as antimycobacterial agents
Recently several 1,3,4-oxadiazole derivatives were identified as potentially active antimycobacterial agents. Various 5-aryl-2-thio-1,3,4-oxadiazoles have been reported having good antimycobacterial activity against Mycobacterium tuberculosis H37Rv (ATCC 27294). In this paper we report 3D QSAR studies for the 41 molecules of 1,3,4-oxadiazoles by using k-Nearest Neighbor Molecular Field Analysis...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Chemical Biology & Drug Design
سال: 2011
ISSN: 1747-0277
DOI: 10.1111/j.1747-0285.2011.01168.x